CovidStanfordV1, Main, Exploration, bibRecord, 000304

Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.

Identifieur interne : 000304 ( Main/Exploration ); précédent : 000303; suivant : 000305

Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.

Auteurs : Silvia Rizzi [Danemark] ; Maarten J. Wensink [Danemark] ; Rune Lindahl-Jacobsen [Danemark] ; Lu Tian [États-Unis] ; Ying Lu [États-Unis] ; Michael L. Eisenberg [États-Unis]

Source :

BMC research notes [ 1756-0500 ] ; 2020.

RBID : pubmed:33160408

Descripteurs français

KwdFr :
- Adulte (MeSH), Antiviraux (effets indésirables), Appréciation des risques (MeSH), Danemark (MeSH), Exposition paternelle (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (traitement médicamenteux), Malformations dues aux médicaments et aux drogues (épidémiologie), Malformations dues aux médicaments et aux drogues (étiologie), Mâle (MeSH), Naissance prématurée (induit chimiquement), Pandémies (MeSH), Pneumopathie virale (traitement médicamenteux), Études de cohortes (MeSH).
MESH :
- effets indésirables : Antiviraux.
- induit chimiquement : Naissance prématurée.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Malformations dues aux médicaments et aux drogues.
- étiologie : Malformations dues aux médicaments et aux drogues.
- Adulte, Appréciation des risques, Danemark, Exposition paternelle, Femelle, Humains, Mâle, Pandémies, Études de cohortes.
Wicri :
- geographic : Danemark.

English descriptors

KwdEn :
- Abnormalities, Drug-Induced (epidemiology), Abnormalities, Drug-Induced (etiology), Adult (MeSH), Antiviral Agents (adverse effects), COVID-19 (MeSH), Cohort Studies (MeSH), Coronavirus Infections (drug therapy), Denmark (MeSH), Female (MeSH), Humans (MeSH), Male (MeSH), Pandemics (MeSH), Paternal Exposure (MeSH), Pneumonia, Viral (drug therapy), Premature Birth (chemically induced), Risk Assessment (MeSH).
MESH :
- chemical , adverse effects : Antiviral Agents.
- geographic : Denmark.
- chemically induced : Premature Birth.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Abnormalities, Drug-Induced.
- etiology : Abnormalities, Drug-Induced.
- Adult, COVID-19, Cohort Studies, Female, Humans, Male, Pandemics, Paternal Exposure, Risk Assessment.

Abstract

OBJECTIVE

With the ongoing COVID-19 pandemic, large numbers of people will receive one of the several medications proposed to treat COVID-19, including patients of reproductive age. Given that some medications have shown adverse effects on sperm quality, there might be a transgenerational concern. We aim at examining the association between drugs proposed to treat COVID-19 when taken by the father around conception and any pre-term birth or major birth defects in offspring in a nation-wide cohort study using Danish registry data. Offspring whose father filled at least one prescription of the following medications in the 3 months preceding conception were considered exposed: chloroquine, hydroxychloroquine, losartan, azithromycin, naproxen, dexamethasone and prednisone.

RESULTS

For azithromycin and naproxen, large numbers of offspring were exposed (> 1800 offspring), and we found no association with adverse birth outcomes. For chloroquine, losartan and dexamethasone, exposure was intermediate (~ 900 offspring), and there was no statistically significant association with birth defects. For hydroxychloroquine and prednisone, exposure was limited (< 300 offspring). Our evidence suggests that azithromycin and naproxen are safe with respect to pre-term birth and birth defects. For the other drugs investigated larger exposures are needed for conclusive statements.

DOI: 10.1186/s13104-020-05358-x
PubMed: 33160408
PubMed Central: PMC7647878

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000180
to stream Main, to step Curation: 000180

Le document en format XML

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<term>Abnormalities, Drug-Induced (etiology)</term>
<term>Adult (MeSH)</term>
<term>Antiviral Agents (adverse effects)</term>
<term>COVID-19 (MeSH)</term>
<term>Cohort Studies (MeSH)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Denmark (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Paternal Exposure (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Premature Birth (chemically induced)</term>
<term>Risk Assessment (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Antiviraux (effets indésirables)</term>
<term>Appréciation des risques (MeSH)</term>
<term>Danemark (MeSH)</term>
<term>Exposition paternelle (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Malformations dues aux médicaments et aux drogues (épidémiologie)</term>
<term>Malformations dues aux médicaments et aux drogues (étiologie)</term>
<term>Mâle (MeSH)</term>
<term>Naissance prématurée (induit chimiquement)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
<term>Études de cohortes (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Denmark</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Premature Birth</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Abnormalities, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Abnormalities, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Naissance prématurée</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Malformations dues aux médicaments et aux drogues</term>
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<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Malformations dues aux médicaments et aux drogues</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>COVID-19</term>
<term>Cohort Studies</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>With the ongoing COVID-19 pandemic, large numbers of people will receive one of the several medications proposed to treat COVID-19, including patients of reproductive age. Given that some medications have shown adverse effects on sperm quality, there might be a transgenerational concern. We aim at examining the association between drugs proposed to treat COVID-19 when taken by the father around conception and any pre-term birth or major birth defects in offspring in a nation-wide cohort study using Danish registry data. Offspring whose father filled at least one prescription of the following medications in the 3 months preceding conception were considered exposed: chloroquine, hydroxychloroquine, losartan, azithromycin, naproxen, dexamethasone and prednisone.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>For azithromycin and naproxen, large numbers of offspring were exposed (> 1800 offspring), and we found no association with adverse birth outcomes. For chloroquine, losartan and dexamethasone, exposure was intermediate (~ 900 offspring), and there was no statistically significant association with birth defects. For hydroxychloroquine and prednisone, exposure was limited (< 300 offspring). Our evidence suggests that azithromycin and naproxen are safe with respect to pre-term birth and birth defects. For the other drugs investigated larger exposures are needed for conclusive statements.</p>
</div>
</front>
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<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">With the ongoing COVID-19 pandemic, large numbers of people will receive one of the several medications proposed to treat COVID-19, including patients of reproductive age. Given that some medications have shown adverse effects on sperm quality, there might be a transgenerational concern. We aim at examining the association between drugs proposed to treat COVID-19 when taken by the father around conception and any pre-term birth or major birth defects in offspring in a nation-wide cohort study using Danish registry data. Offspring whose father filled at least one prescription of the following medications in the 3 months preceding conception were considered exposed: chloroquine, hydroxychloroquine, losartan, azithromycin, naproxen, dexamethasone and prednisone.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">For azithromycin and naproxen, large numbers of offspring were exposed (> 1800 offspring), and we found no association with adverse birth outcomes. For chloroquine, losartan and dexamethasone, exposure was intermediate (~ 900 offspring), and there was no statistically significant association with birth defects. For hydroxychloroquine and prednisone, exposure was limited (< 300 offspring). Our evidence suggests that azithromycin and naproxen are safe with respect to pre-term birth and birth defects. For the other drugs investigated larger exposures are needed for conclusive statements.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rizzi</LastName>
<ForeName>Silvia</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-3512-2361</Identifier>
<AffiliationInfo><Affiliation>Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Interdisciplinary Centre on Population Dynamics, University of Southern Denmark, Odense, Denmark.</Affiliation>
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<Author ValidYN="Y"><LastName>Wensink</LastName>
<ForeName>Maarten J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Interdisciplinary Centre on Population Dynamics, University of Southern Denmark, Odense, Denmark.</Affiliation>
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<Author ValidYN="Y"><LastName>Lindahl-Jacobsen</LastName>
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<AffiliationInfo><Affiliation>Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Interdisciplinary Centre on Population Dynamics, University of Southern Denmark, Odense, Denmark.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Tian</LastName>
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<AffiliationInfo><Affiliation>Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, USA.</Affiliation>
</AffiliationInfo>
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<ForeName>Ying</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, USA.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Eisenberg</LastName>
<ForeName>Michael L</ForeName>
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<AffiliationInfo><Affiliation>Male Reproductive Medicine and Surgery, Department of Urology and Obstetrics & Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, S-287, Stanford, CA, USA. meisenb@stanford.edu.</Affiliation>
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<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>HD096468</GrantID>
<Acronym>NH</Acronym>
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<Country>United States</Country>
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<CommentsCorrectionsList><CommentsCorrections RefType="UpdateOf"><RefSource>Res Sq. 2020 Aug 26;:</RefSource>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000014" MajorTopicYN="N">Abnormalities, Drug-Induced</DescriptorName>
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<ArticleIdList><ArticleId IdType="pubmed">32363333</ArticleId>
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<Reference><Citation>Int J Epidemiol. 2017 Jun 1;46(3):798-798f</Citation>
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Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.

Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.

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